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Virus Name: Akabane

Abbreviation: AKAV

Status
Probable Arbovirus

Select Agent
No

SALS Level
3

SALS Basis
Results of SALS surveys and information from the Catalogue.

Other Information
USDA Permit Required, Hepa Filtration, USDA Restricted, USDA High Consequence Agent

Antigenic Group
Simbu

Section VIII - Susceptibility to Experimental Infection (include viremia)

Experimental host and age	Passage history and strain	Inoculation Route-Dose	Evidence of infection	AST (days)	Titer log10/ml


Mice (nb)	SMB 1	ic 0.02	Illness and death	2-5	9.7
Mice (nb)		ip
Mice (nb)		sc
Mice (wn)		ic 0.03	Illness and death	3-6	8.1
Mice (wn)		ip
pregnant ewes	SM 3 Cow 1 SM 2		Congenital malformations (arthrogryposis-hydranencephly syndrome) in foetal lambs. NT antibody to AKA in lambs (9).



bulls			Viremia 2-9 days pi for 3-5 days. NT antibody by 7-10 days. Virus not isol. from semen (13)



embryonated eggs (4 days)		ys	Death or developmental abnormalities including arthrogryposis (12).


embryonated eggs (6 days)		ys	Myopathy and encephalopathy (15).

embryonated eggs (15 days)		iv	Foci of encephalitis including neuronal degeneration (15).

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