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Virus Name: Crimean Hemorrhagic Fever

Abbreviation: CHFV

Status
Arbovirus

Select Agent
No

SALS Level
4

SALS Basis
Level assigned to prototype or wild-type virus. A lower level may be recommended for laboratory strains or geographic variants of the virus with well-defined reduced virulence characteristics, as mentioned in the text.

Other Information

Antigenic Group
CHF-Congo

Section V - Antigenic Relationship and Lack of Relationship to Other Viruses

Summary of studies on the antigenic relationships of the CHF-Congo group viruses [13] . For other pertinent studies, see References [1] , [4] , [14] , and [16] .

Tests	CF ^a			AGDP ^b			NT ^c			IFA ^d
	Sera
	CHF	CON	HAZ	CHF	CON	HAZ	CHF	CON	HAZ	CHF	CON	HAZ
Antigens	Khodzha	JD 206	JC 280	Khodzha	JD 206	JC 280	Khodzha	JD 206	JC 280	Khodzha	IbAr 10200	JC 280


^a Antigen titer/serum titer; 0 = <5/<4
^b + = precipitation bands present, 0 = negative result (tissue culture antigens concentrated with PEG were used in the tests).
^c LNI determined in newborn mice and expressed in dex.
^d Mean percent of the number of the antigen-containing cells to the number of the examined cells in each preparation (culture of 6619 cells).




CHF, Khodzha	80/128	80/128	0	+	+	0	2.8	2.5	0.7	75%	70%	0

Congo,(CON) IbAr10200	80/128	80/128	0	+	+	0	2.3	2.8	1.0	85%	85%	0

Congo, JD 206	80/128	80/128	80/16	+	+	0	2.0	2.8	1.1	60%	65%	0

Hazara.(HAZ) JC 280	0	0	80/256	0	0	0	0.7	0.6	2.5	0	0	45%

Lack of relationship with viruses of tickborne encephalitis, Omsk hemorrhagic fever, hemorrhagic fever with renal syndrome, Bolivian hemorrhagic fever, Argentinean hemorrhagic fever, Kyasanur Forest disease, Kemerovo, Bandia, Bhanja, Chenuda, Colorado tick fever, Uukuniemi, Wad Medani, and West Nile.

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