| | | DEN-2 virus is antigenically closely related to other types of DEN viruses. Currently, the dengue viruses are considered to be related more closely to each other than to other flaviviruses. The dengue viruses comprise a separate complex in serogroup B ( [27] , [28] ). (See first two paragraphs for DEN-1, Section 5, for more detail regarding common antigens and strain variation.) | | TH-36, previously listed as in the Catalogue (No. 262) was suggested as a possible type 5 since it was isolated from one of the early Thai hemorrhagic fever cases in Bangkok in 1958 ( [12] - [14] ) and was found eventually to differ antigenically to a significant degree from type 2 New Guinea C prototype. Differences have been shown by CF ( [13] , [14] ), immunodiffusion [15] and immuno- electrophoresis [16] but not by soluble CF (SCF) antigen [17] . It is generally accepted that strain differences among DEN viruses may be rather prominent. Their significance is as yet unknown. | | |
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