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  Iaco   IACOV

Possible Arbovirus

No

3

Isufficient experience with virus; i.e., experience factor from SALS surveys was less than 500 in laboratory facilities with low biocontainment.
Other Information
 

Bunyamwera
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
BeAr 314206 is a member of the Bunyamwera group as shown below:
 
Complement-Fixation Test
Sera
Antigens BeAr 314206 SOR Macaua BeAr 328208 (Tucunduba) MAG KRI GRO Gr. Bunyamwera


a Serum titer/antigen titer; 0 = <4/<4
BeAr 314206 >256/>256a 8/>=256 8/>256 4/256 0 0 0 0 4/8
Sororoca 16/64 256/>256 8/64 16/>=256 0 0 0 0 >=16/>=8
Macaua 16/>=256 16/>=256 256/>256 0 0 0 0 0 8/>=8
BeAr 328208 16/32 64/64 8/32 64/64 0 0 0 8/>=8 >=16/>=8
(Tucunduba) 0 16/>=256 16/>=256 0 64/>256 >=16/>=8
At YARU, BeAr 314206 CF antigen did not react with hyperimmune sera against Batai, Germiston, Ilesha, Lokern, Main Drain, Northway, Tensaw, Playas, Bunyamwera and Santa Rosa viruses. Antigenic relationship was demonstrated with Tlacotalpan, Anhembi, Birao and Shokwe viruses. PRNT in Vero cells gave the following results:
 
Plaque Reduction Neutralization Test
Sera
Viruses BeAr 314206 Macaua BeAr 328208 ANH BIR Shokwe SOR


b Reciprocal of hightest dilution giving 80% plaque reduction in Vero cell cultures
BeAr 314206 2048b 8 64-128 512 <8 <8 32-64
Macaua 8 64-128 <8 8 8 <8 <8
BeAr 328208 32 16 128 8 <8 <8 32-64
Anhembi 16 512
Sororoca 16 <8 32-64 32-64
 
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