| |
| Results of complement-fixation tests with the human isolate and other members of the CAL group [1] . |
| |
| | Mouse hyperimmune sera: |
|---|
| Antigens | LAC | BFS283 | SSH | TVT | Melao |
|---|
|
| | Antigen titer/antibody titer | | La Crosse | 128/>512 | 8/>512 | 8/512 | 8/512 | 8/512 | | BFS-283 | 32/64 | 32/128 | 8/256 | 8/128 | 8/256 | | Snowshoe hare | 32/256 | 8/256 | 32/256 | 16/128 | 8/256 | | TVT | <8/<8 | 8/128 | <8/<8 | 64/128 | 8/64 | | Melao | 32/256 | <8/<8 | <8/<8 | 16/128 | 32/256 |
|
| Results of additional comparative CF, NT and immunodiffusion tests have since been reported also indicating serologic relationship of the La Crosse isolate to, but antigenic differences from, other California group viruses. [4] , [5] , [6] |
| Results of neutralization tests with antisera to isolates from Wisconsin mosquitoes [7] . |
| |
| | Virus |
|---|
| | La Crosse | Snowshoe hare | Jamestown Canyon | Trivittatus |
|---|
| Antisera | (199 TCID50) | (31 TCID50) | (31 TCID50) | (63 TCID50) |
|---|
|
| | Antisera: prepared in guinea pigs. | | ( ): Dosage of virus in test. | | a Reciprocal of highest dilution which neutralized CPE activity of virus in BHK-21 cells. | | <10: 50% of cells alive, but some CPE evident at this dilution. | | W-1805-64 | 40 a | 20 | 20 | 10 | | W-2827-65 | 120 | 60 | <10 | <10 | | W-2985-65 | 160 | 20 | 80 | 20 | | W-401-67 | 640 | 40 | 15 | 30 | | W-581-67 | 80 | 30 | 30 | 15 | | W-968-67 | >1280 | 30 | 80 | 80 | | W-946-67 | 160 | 15 | 20 | 15 | | W-1042-68 | 320 | 160 | 80 | 20 | | LAC | 640 | 80 | 20 | 10 | | SSH | 40 | 320 | 20 | <10 | | JC | <10 | <10 | 640 | <10 | | TVT | <10 | <1- | 20 | 160 |
|
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