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Virus Name: Latino

Abbreviation: LATV

Status
Not Arbovirus

Select Agent
No

SALS Level
2

SALS Basis
Level 2 arenaviruses are not known to cause serious acute disease in man and are not acutely pathogenic for laboratory animals, including primates. Survey experience is sufficient to conclude that laboratory aerosol infection does not occur in the course of routine work with cell cultures and animals not subject to chronic infection. In view of reported high frequency of laboratory aerosol infection that occurred in workers manipulating high concentrations of Pichinde virus, it is strongly recommended that work with high concentrations of Level 2 arenaviruses be done at Level 3.

Other Information

Antigenic Group
Tacaribe

Section V - Antigenic Relationship and Lack of Relationship to Other Viruses

	Latino Antigen		Latino Hamster-Immune Sera
CF Immune Sera, Antigens	Ht/Ho	Ratio	Ht/Ho	Ratio


Machupo	32/256	1/8	64/256	1/4
Junin	32/128	1/4	64/256	1/4
Tacaribe	8/64	1/8	32/256	1/8
Amapari	8/64	1/8	32/256	1/8
Tamiami	<8/64	<1/8	<8/256	<1/32
Pichinde	8/128	1/16	4/256	1/64
Parana	16/512	1/32	16/256	1/16

Neutralization:

Plaque reduction in Vero cells. Serum NT antibody titer Ho = 32 ; Ht <4

Direct Immunofluorescence:

2+ fluorescence, Latino antiserum against Pichinde viral antigen (Vero cells). No cross-reaction with other Tacaribe serogroup members.

Indirect Immunofluorescence:

1+ fluorescence Latino antiserum against LCM infected cells 3T3 (viral antigen). No cross-reaction with other Tacaribe serogroup members.

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