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Virus Name: Macaua

Abbreviation: MCAV

Status
Probable Arbovirus

Select Agent
No

SALS Level
3

SALS Basis
Isufficient experience with virus; i.e., experience factor from SALS surveys was less than 500 in laboratory facilities with low biocontainment.

Other Information

Antigenic Group
Bunyamwera

Section V - Antigenic Relationship and Lack of Relationship to Other Viruses

CF tests performed in Belem showed that Macaua virus shares an antigenic relationship with viruses of the Bunyamwera group.

Complement-Fixation Test
	Sera
Antigens	Macaua	Iaco	BeAr 328208	Tucunduba	MAG	KRI	GRO	SOR


^b Serum titer/antigen titer; 0 = <4/<4
Macaua	256/>256 ^b	16/>=256	0	0	0	0	0	16/>256
Iaco	8/>=256	>=256/>=256
BeAr 328208	8/32		64/64
Tucunduba	16/>=256			64/>=256
Maguari	0				>=32/>=40
Kairi	0					16/>=64
Guaroa	0						>=32/>=40
Sororoca	8/64							256/>=256

PRNT in Vero cells [1]
	Sera
Virus	Macaua	Iaco	BeAr 328208	Tucunduba	Taiassui	SOR	BAT	NOR	AMB	BUN	BIR	SHO


^c Reciprocal of highest dilution giving 80% plaque reduction
Macaua	128 ^c	8	<8	<8	16	<8	<8	8	8	<8	8	<8
Iaco	8	2048
BeAr 328208	16		128
Tucunduba				64
Taiassui	16				512
Sororoca						64-128

At YARU, Macaua CF antigen did not react with hyperimmune sera of Germiston, Ilesha, Lokern, Main Drain, Tensaw, Tlacotalpan and Playas viruses. Antigenic relationship was demonstrated with Batai, Northway, Anhembi, Bunyamwera, Santa Rosa, Birao, and Shokwe viruses. Sera of these viruses did not neutralize Macaua virus by PRNT in Vero cell cultures [1] .

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