| | | IFA: not related to CCHF, RVF, Ebola, Marburg, Hanta. Related to Lassa, LCM, Mopela, Ippy but distinguishable by monoclonal antibody generated against NP and GP of Lassa and Mopela [1] - [4] . | | | | IFA REACTIONS OF 9 CENTRAL AFRICAN REPUBLIC (CAR) MOBALA VIRUS STRAINS TO MONOCLONAL ANTIBODIES MADE AGAINST LASSA, MOZAMBIQUE (MOZ) AND LCM ANTIGENS. |
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| | 9 Strains of Mobala virus | Antigen |
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| Antibody | Lassa | MOZ | LCH |
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| | a Number in parentheses is the number of monoclones tested. | | b Number of monoclones reacting to antigen over number of monoclones tested. | | c I Lassa specific and 2 Lassa and MOZ monoclones not tested against LCM. | | Human anti-lassa serum | + | + | + | + | | Monoclonal antibodies | | | | | Lassa specific (5) a | 0/5 b | 5/5 | 0/5 | 1/4 c | | MOZ specific (2) | 0/2 | 0/2 | 2/2 | 0/2 | | Lassa and MOZ spec. (11 ) | 9/11 | 11/11 | 11/11 | 6/9 c | | LCM (2) | 0/2 | 1/2 | 2/2 | 2/2 |
| | Neutralization tests by the log neutralization index (LNI) method readily differentiated Mobala virus in both directions from 3 strains of Lassa, Mopela and LCM viruses [9] . | | | | Relationships among Old World arenaviruses by the neutralization test (log neutralization index determined by reduction of plaques) [9] . |
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| Guinea pig immune serum | LNI of antiserum against virus from |
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| Virus | Strain | Origin | SL. | LIB/G | NIG | MOZ | CA | LCM |
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| | Lassa | Josiah | Sierra Leone (SL) | 3.6 | 3.5 | 1.0 | 1.4 | 0.7 | 0.8 | | Lassa | Z-158 | Liberia/Guinea (LIB/G) | 2.6 | 3.5 | 1.5 | 1.5 | 1.2 | 0.4 | | Lassa | JW | Nigeria (NIG) | 1.2 | 1.4 | 3.6 | 1.0 | 0.2 | 0.5 | | Mopeia | 20410 | Mozambique (MOZ) | <0.3 | <0.3 | <0.3 | 2.4 | 0.6 | <0.3 | | Mobala | 3080 | Central Africa (CA) | <0.3 | <0.3 | <0.3 | 0.3 | 2.2 | <0.3 | | LCM | Armstrong | USA | <0.3 | <0.3 | <0.3 | <0.3 | 0.6 | 3.9 |
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