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Virus Name: Munguba

Abbreviation: MUNV

Status
Possible Arbovirus

Select Agent
No

SALS Level
3

SALS Basis
Isufficient experience with virus; i.e., experience factor from SALS surveys was less than 500 in laboratory facilities with low biocontainment.

Other Information

Antigenic Group
Phlebotomus fever

Section V - Antigenic Relationship and Lack of Relationship to Other Viruses

Serological studies carried out in Brazil showed that virus strain BeAr 389707 was related by CF and NT to viruses of the Phlebotomus fever group.

Complement-Fixation Test
	Sera
Antigens	BeAr 389707	ICO	BUJ	ITP	URU	CDU	ITA	ALE	TUA	PAC	ANH


^a Serum titer/antigen titer; 0 = <4/<4
BeAr 389707	>=128/>=64 ^a	0	4/8	0	0	0	0	0	0	0	0
Icoaraci	0	>=128/>=64
Bujaru	>=128/>=64		32/>=64
Itaporanga	0			>=16/>=64
Urucuri	0				>=128/>=64
Candiru	0					>=128/>=64
Itaituba	0						>=128/>=64
Alenquer	0							64/>=64
Turuna									>=128/>=64
Pacui										128/>=64
Anhanga											32/64

Results of Neutralization Tests Performed in Newborn Mice, ic Route
	Sera
Viruses	BeAr 389707	ICO	BUJ	ITP	URU	CDU	ITA	ALE	TUA	PAC	ANH


^b LNI in dex
BeAr 389707	4.0 ^b	0.2	0.2	<=0.1	0.5	0.2	0.0	0.0	0.2	0.2	0.2
Bujaru	2.5		2.7

The CF results were confirmed at YARU, and it showed that this virus was not related to Arumowot, Buenaventura, Cacao, Caimito, Chilibre, Frijoles, Gabek Forest, Gordil, Karimabad, Naples, Nique, Punto Toro, Rift Valley fever (serum only), Rio Grande, Saint- Floris, Salehabad, Sicilian, Teheran, and Toscana viruses. BeAr 389707 antigen showed a slight cross-reaction with Chagres and Aguacate sera. Virus strain BeAr 389707 did not cross-react in plaque-reduction neutralization tests when it was tested against antisera to Chagres, Aguacate, and Bujaru viruses.

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