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Virus Name: Nairobi sheep disease

Abbreviation: NSDV

Status
Arbovirus

Select Agent
No

SALS Level

SALS Basis

Other Information
USDA Permit Required, USDA Restricted

Antigenic Group
Nairobi Sheep Disease

Section VIII - Susceptibility to Experimental Infection (include viremia)

Experimental host and age	Passage history and strain	Inoculation Route-Dose	Evidence of infection	AST (days)	Titer log10/ml


Mice (nb)	P 1-8	ic 0.01	Death	5	7.0
Mice (nb)		ip 0.01	Death	5-10	3.0
Mice (nb)		sc
Mice (wn)		ic 0.03	Death	5	6.0
Mice (wn)		ip 0.1	Antibody formation
Mice (nb)	P 110+	all 0.01	Death	2.0	10.0
Mice (ad)	vaccine in mice	ic 0.03	Death	2.5	9.5
Mice		ip 0.03	Death	2.5	9.5
sheep (ad)	Wild	ip 0.5)	Almost invariably		7.0
		sc 0.5)	fatal gastroenteritis	4-7	7.0
		iv 0.5)	Same
(ad)	Vaccine	all 0.5)	Mild thermal reaction;	4-7	7.0
(lamb)		all 0.5	viremia, antibody formation
embryonated egg	Both	all	Only an occasional embryo
(7+12 day)		conventional	infected and then virus growth minimal
Arvicanthis niloticus (ad)	Both	ip 0.1	Viremia		5.0

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