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  Nique   NIQV

Possible Arbovirus

No

2

Results of SALS surveys and information from the Catalogue.
Other Information
 

Phlebotomus Fever
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
Nique CF antigen (homologous = >2056/512) did not react with immune sera for Groups A, B, C, PHL, TCR, CAP, SIM, CAL, and BUN; or with specific antisera for ANA, ANB, TUR, MAN, VSI, VSNJ, VSA, COC, PIRY, CHP, PAC, CGL, SFN, SFS, PT, CHG, ICO, CDU, ITP, KAR, ANH, BW, AMT, GF, URU, BUE, SAL, FRI, CHI, CAI, CAC and AGU.
Nique hyperimmune hamster serum did not react in CF tests with suckling hamster brain antigens for SFN, SFS, CHG, ICO, ITP, KAR, ANH, PAC, BUJ, AMT, GF, BUE, SAL, CAC, URU, FRI, CAI, CHV and AGU viruses [1] .
CF or NT relationships were demonstrated between Nique and four other Phlebotomus fever group agents (Candiru, Punta Toro, Icoaraci and Agucate) as noted below.
 
Antigen or Virus
Nique Candiru Punta Toro Aguacate Icoaraci
Antiserum CF NT CF NT CF NT CF NT CF NT


CF: Antibody titer/antigen titer; 0 = <4/<4.
NT: Results as reciprocal of highest serum dilution producing >90% plaque reduction; 0 = <16.
Nique >2048/512 128 8/64 16 16/64 0 16/16 0 0 16
Candiru 128/512 0 256/512 512 0 0 0 0 0 0
Punta Toro 0 64 0 512 64/256 8192 0 0 0 64
Agucate 0 0 0 0 0 0 >512/128 512 0 0
Icoaraci 0 32 0 512 0 1024 0 0 >2048/256 32000
Cross-neutralization tests (plaque method) using Nique virus and hyperimmune serum (homologous titer = 128) were done against each of the following viruses and specific antisera with negative results: SFN, SFS, CHG, GF, RVF, ITP, KAR, ANH, BUJ, AMT, BUE, SAL, ITA, GOR, SAF, SAL, URU, TUA, FRI, CAI, CHI, CAC, and CHV [1] , [2] .
In addition, see References [4] , [5] .
 
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