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Virus Name:
Royal Farm
Abbreviation:
RFV
Status
Possible Arbovirus
Select Agent
No
SALS Level
2
SALS Basis
Results of SALS surveys and information from the Catalogue.
Other Information
Antigenic Group
B
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
Relationship of Royal Farm virus by CF using immune serum to Royal Farm virus against antigens of 40-odd members of group B at NAMRU-3, YARU, and the Pasteur Institut, Dakar, gave titers of <16 with the exception of Langat and Powassan as shown in the table below.
HI and CF Tests
Royal Farm Antigen
Royal Farm Immune Serum (2)
HI
CF
HI
CF
Immune Sera
Ht/Ho
Ratio
Ht/Ho
Ratio
Antigens
Ht/Ho
Ratio
Ht/Ho
Ratio
( ): Number of ip injections administered to mice
HI: serum diluted 1:5; 4 units of antigen used.
Langat (3)
40/160
1/4
16/64
1/4
Langat
20/160
1/8
16/64
1/4
Powassan (6)
20/40
1/2
64/64
1
Powassan
10/40
1/4
l6/64
1/4
Neutralization Tests
Royal Farm Virus
a
Royal Farm Serum
b
Undiluted
1:10
1:16
Undiluted
1:10
1:16
Immune Serum
Ht/Ho
Ht/Ho
Ht/Ho
Virus(a)
Ht/Ho
Ht/Ho
Ht/Ho
a
Freshly prepared virus in its 10th mouse brain passage was used.
b
Sera used in the neutralization tests were produced by one formalized and 2 live injections at 14-day intervals; 5 injection Langat serum was used in the 1:16 dilution neutralization test; neutralization test results as LNI in dex.
Langat (3)
b
1.5/4.3
3.0/5.5
2.3/4.0
Langat
6.0/1.5
7.3/3.3
5.0/2.3
Powassan (3)
4.0/6.3
Powassan
9.3/2.3
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