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Virus Name: Russian Spring Summer Encephalitis

Abbreviation: RSSEV

Status
Arbovirus

Select Agent
Yes

SALS Level
4

SALS Basis
Results of SALS surveys and information from the Catalogue.

Other Information
DOC Permit Required

Antigenic Group
B

Section VIII - Susceptibility to Experimental Infection (include viremia)

Experimental host and age	Passage history and strain	Inoculation Route-Dose	Evidence of infection	AST (days)	Titer log10/ml


Il'yenko and colleagues reported that several weeks after ic inoc. with certain strains of TBE virus, some rhesus monkeys surviving acute encephalitis developed chronic atheototic movement disorders (19-21). This finding has been confirmed independently for the Vasil'chenko strain (22).

Mice (nb)	Not generally	ic 0.01	Encephalitis and death	3-6	7-9
Mice (nb)	available	ip 0.03	Encephalitis and death	3-6	7-9
Mice (nb)		sc
Mice (wn)		ic 0.03	Encephalitis and death	3-6	7-8
Mice (wn)		ip 0.25	Encephalitis and death	3-6	6-7
Syrian hamster (3-4 wk)		ic 0.03	Encephalitis and death	4-8	6-8
Syrian hamster (3-4 wk)		ip 0.25	Encephalitis and death	4-12	5-7
white rats (1-2 day)		ic 0.05	Encephalitis and death	4-6	7.2
domestic pigs (3-4 wk)		ic 0.2	Encephalitis and death	4-8	7
sheep (3-4 mo)		ic 0.5	Encephalitis and death	7-8
guinea pigs (50-60 gm)		ic 0.1	Encephalitis and death	7-8	4-6
rhesus monkey (2-3 kg)		inthra-thalamic 0.5x2	Paralysis	5-15
chick embryo (8-9 day)		ys 0.2	Death and/or passage to mice	3-5	6-8
chick embryo (8-9 day)		CAM 0.2	Death and/or passage to mice

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