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Virus Name:
Semliki Forest
Abbreviation:
SFV
Status
Arbovirus
Select Agent
No
SALS Level
3
SALS Basis
Fatal human laboratoryinfection, 1978, probably aerosol. This is recognized to be a unique incident in a long history of work with SFV under minimal biocontainment conditions. However, since the virulence characteristics of the strain responsible in this case require further study and the prevalence of subclinical infections in laboratories working with SFV remains unknown, the committee recommends Level 3 until further information is available warranting reconsideration at a lower level.
Other Information
Antigenic Group
A
Section X - Histopathology
Character of lesions (specify host)
In experimental animals: viral encephalitis, hyperamia of renal cortex, intestinal haemorrhage and mononuclear infiltration (1). In chick embryos, scattered necrotic cells (12).
Inclusion Bodies
Intranuclear
Organs/Tissues Affected
Brain (LV); kidney (LV)
Category of tropism
Neurotropic
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