Centers for Disease Control and Prevention
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ARBOVIRUS A-Z Index
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Method of Isolation
Natural Host Range
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Level 2 arenaviruses are not known to cause serious acute disease in man and are not acutely pathogenic for laboratory animals, including primates. Survey experience is sufficient to conclude that laboratory aerosol infection does not occur in the course of routine work with cell cultures and animals not subject to chronic infection. In view of reported high frequency of laboratory aerosol infection that occurred in workers manipulating high concentrations of Pichinde virus, it is strongly recommended that work with high concentrations of Level 2 arenaviruses be done at Level 3.
** Newborn mice inoc. ic showed choroiditis, gliosis vasculitis, perivasculitis with lymphocytic infiltration in CNS. Thymectomy abolished histopath. response (9).
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