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Virus Name:
Tacaribe
Abbreviation:
TCRV
Status
Not Arbovirus
Select Agent
No
SALS Level
2
SALS Basis
Level 2 arenaviruses are not known to cause serious acute disease in man and are not acutely pathogenic for laboratory animals, including primates. Survey experience is sufficient to conclude that laboratory aerosol infection does not occur in the course of routine work with cell cultures and animals not subject to chronic infection. In view of reported high frequency of laboratory aerosol infection that occurred in workers manipulating high concentrations of Pichinde virus, it is strongly recommended that work with high concentrations of Level 2 arenaviruses be done at Level 3.
Other Information
Antigenic Group
Tacaribe
Section VIII - Susceptibility to Experimental Infection (include viremia)
Experimental host and age
Passage history and strain
Inoculation Route-Dose
Evidence of infection
AST (days)
Titer log10/ml
Artibeus jamaicensis trinitatis and A. lituratus palmarum inoculated intramuscularly with 10,000 LD50. No circulating virus. Virus recovered from occasional animal one to two weeks post-inoculation. No pre-immunity detectable by NT. Post-inoculation immunity detectable in only one animal (1). Desmodus rotundus (""vampire"" bat) no detectable pre-immunity. Inoculated IM with 185 LD50; 4 out of 20 bats with virus in organs at 5 and 7 days (1).
* When infecting dose is about 100 LD50
Mice (nb)
SMB 18
ic 0.02
Death
9*
6.5
Mice (nb)
ip 0.03
Death
11*
2.0
Mice (nb)
sc
Mice (wn)
ic 0.03
Death
7
2.0
Mice (wn)
ip 0.5
No illness
emb eggs (6 day)
SMB 20
ys 0.5
Kills embryos irregularly
7-8
am.s.
No propagation
al.c.
No propagation
rabbit (ad)
ip
No illness; antibodies
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