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Virus Name: Benfica

Abbreviation: BENV

Status
Arbovirus

Select Agent
No

SALS Level
2

SALS Basis
Placed at this biosafety level based on close antigenic or genetic relationship to other viruses in a group of 3 or more viruses, all of which are classified at this level.

Other Information

Antigenic Group
Capim

Section V - Antigenic Relationship and Lack of Relationship to Other Viruses

Benfica virus has been shown to fall in the Capim group. Cross CF, HI, and neutralization tests gave the following results:

CF
ANTIGENS
Sera	Capim	Guajara	Bushbush	Moriche	Acara	Benfica	Benevides


^* Antibody/antigen titers; 0 = <4/<4
Capim	64/>256^*	8/16	0	0	0	0	0
Guajara	0	32/16	0	0	0	0	0
Bushbush (BeAn 20076)	0	8/16	32/16	32/>256	0	0	0
Moriche	0	32/16	>256/16	>256/>256	0	0	0
Acara	0	0	0	0	16/>256	8/64	16/>256
Benfica	0	0	0	0	16/>256	32/64	32/>256
Benevides	0	0	0	0	16/>256	8/64	32/>256

HI
ANTIGENS (4 Units)
Sera	Capim	Guajara	Bushbush	Moriche	Acara	Benfica	Benevides


Capim	80	0	0	0	0	0	0
Guajara	0	80	0	0	0	0	0
Bushbush	0	0	80	0	0	20	0
Moriche	0	0	0	160	40	0	0
Acara	0	0	0	0	40	0	0
Benfica	0	0	20	0	0	80	0
Benevides	0	0	0	0	0	0	40

NEUTRALIZATION (Infant mice, ic route)
Virus
Sera	Acara	Benfica	Benevides


^** LNI in dex
Acara	> 6.2^**	0.1	0.1
Benfica (An 84381)	<1.2	> 5.1	0.1
Benevides (An 153564)	<1.2	0.1	>5.1

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