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Virus Name:
Bluetongue
Abbreviation:
BLUV
Status
Arbovirus
Select Agent
No
SALS Level
2
SALS Basis
Results of SALS surveys and information from the Catalogue.
Other Information
USDA Permit Required, USDA Restricted, USDA High Consequence Agent
Antigenic Group
Bluetongue
Section VI - Biologic Characteristics
Virus Source (all VERTEBRATE isolates)
Blood (LV), CNS (LV), spleen (LV), skin lesions (LV), lymph node (LV); fetal: calf spleen; sheep CNS, liver, lung; lab. mice CNS. Bovine and ovine placenta
Lab Methods of Virus Recovery (ALL ISOLATIONS)
Newborn mice, chick embryos and Vero cell cultures, BHK-21.cell cultures
Cell system (a)
Virus passage history (b)
Evidence of Infection
CPE
PLAQUES
Growth Without CPE
Day (c)
Extent (d)
Titer TCD50/ml (e)
Day (c)
Size (f)
Titer PFU/ml (e)
+/- (g)
Hamster kidney (BHK-21) cell cultures are commonly used. Virus multiplication is noted and is accompanied by the production of CPE (34). Other cell lines used are Vero and L mouse fibroblasts. Bluetongue virus multiplies without CPE in Aedes albopictus and Ae pseudoscutellaris cell cultures at 27C and 37C. Maximum titers are detected on days 3 and 6 respectively. Viral multiplication was not demonstrated in Ae aegypti cell cultures (15).
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