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Abbreviations
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Virus Name: Bluetongue

Abbreviation: BLUV

Status
Arbovirus

Select Agent
No

SALS Level
2

SALS Basis
Results of SALS surveys and information from the Catalogue.

Other Information
USDA Permit Required, USDA Restricted, USDA High Consequence Agent

Antigenic Group
Bluetongue

Section VIII - Susceptibility to Experimental Infection (include viremia)

Experimental host and age	Passage history and strain	Inoculation Route-Dose	Evidence of infection	AST (days)	Titer log10/ml


Experimental hosts are sheep, cattle, goats, some wild ruminants, suckling mice, and hamsters, embryonating chicken eggs, and certain cell lines. CF antigen is usually prepared from baby mice, or cell cultures.
Experimental results depend on the strain of BLU used (3,10).
Several findings promoted experimental BLU research (3,10): the showing of the plurality of strains (23), the successful use of the propagation of BLU inembryonated chicken eggs(1), the development of cell culture as a neutralization assay system (8), and the demonstration for wild and colonized populations of C. variipennis that this species was a biological vector of bluetongue virus(7). Subsequent research in the USA showed the viremic curves of BLU in sheep andcattle (18). A genetic selection program for oral susceptibility to BLUdeveloped two highly susceptible and a resistant line from the baseline colony of C. variipennis (Sonora strain) that was only 30% susceptible (16).
Mice (nb)		ic
Mice (nb)		ip
Mice (nb)		sc
Mice (wn)		ic
Mice (wn)		ip

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