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  Buenaventura   BUEV

Possible Arbovirus

No

3

Isufficient experience with virus; i.e., experience factor from SALS surveys was less than 500 in laboratory facilities with low biocontainment.
Other Information
 

Phlebotomus Fever
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
Buenaventura antigen and hyperimmune serum (homologous titer = 64/512) did not react in cross-CF tests with the following antigens and immune sera: Frijoles, Caimito, Nique, Aguacate, Cacao, Chagres, Candiru, Itaporanga, Urucuri, Pacui, Anhanga, Bujaru, Arumowot, Sicilian, Naples, Gabek Forest, Karimabad, Salehabad, Alenquer, Itaituba, and Charleville [1] .
Cross-neutralization tests (plaque method) using Buenaventura virus and hyperimmune serum (homologous titer = 128) were done against each of the following viruses and specific antisera with negative results: Frijoles, Caimito, Nique, Aguacate, Chilibre, Cacao, Chagres, Candiru, Itaporanga, Urucuri, Pacui, Anhanga, Bujaru, Arumowot, Sicilian, Naples, Gabek Forest, Karimabad, Salehabad, Gordil, Saint Floris, Rio Grande, Alenquer, Itaituba and Charleville [1] .
Antigenic relationships between Buenaventura, Punta Toro and Icoaraci by both CF and NT were noted as follows [1] :
 
Antigen/Virus
Buenaventura Punta Toro Icoaraci
Antiserum CF NT CF NT CF NT


CF: Antibody titer/antigen titer
NT: Reciprocal of highest serum dilution producing >90% plaque reduction
Buenaventura 64/512 128 <4/<4 32 <4/<4 <16
Punta Toro 8/32 256 64/256 8192 <4/<4 64
Icoaraci 8/16 32 <4/<4 1024 >2048/256 32000
Buenaventura hyperimmune serum (homologous titer not determined) was tested by HI against 9 other PHL group antigens with the following results: Frijoles (<10), Aguacate (20), Chagres (<10), Icoaraci (80), Itaporanga (10), Anhanga (<10), Arumowot (10), Sicilian (<10) and Karimabad (<10) [1] .
 
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