Toxicological Profile for Nickel

CAS#: 7440-02-0

Draft for Public Comment
Comments may be submitted via
Public Comment Period Closed on November 28, 2023

Toxicological Profile Information

The ATSDR toxicological profile succinctly characterizes the toxicology and adverse health effects information for the toxic substance described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicological properties.

A useful two page information sheet, the ToxFAQs™, is also available.

Toxicological Profile Access

In order to access the ATSDR toxicological profile PDF files below, you must have Adobe Acrobat Reader. You may download that program free from Adobe.

Complete Profile pdf icon[PDF - 13.3 MB]

Preface pdf icon[PDF - 1 MB]

1. Relevance to Public Health pdf icon[PDF - 9.16 MB]

2. Health Effects pdf icon[PDF - 1.7 MB]

3. Toxicokinetics, Susceptible Populations, Biomarkers, Chemical Interactions pdf icon[PDF - 535 KB]

4. Chemical and Physical Information pdf icon[PDF - 234 KB]

5. Potential for Human Exposure pdf icon[PDF - 750 KB]

6. Adequacy of the Database pdf icon[PDF - 229 KB]

7. Regulations and Guidelines pdf icon[PDF - 153 KB]

8. References pdf icon[PDF - 359 KB]

Appendices pdf icon[PDF - 1.38 MB]


Agency for Toxic Substances and Disease Registry (ATSDR). 2023. Toxicological Profile for Nickel (Draft for Public Comment). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.


All ATSDR toxicological profile PDF files are electronic conversions from other electronic text files. This conversion may have resulted in character translation or format errors.

Regulations or guidelines may change. Please check with the appropriate agency for any changes to the regulations or guidelines cited.

Where can I get more information?

If you have questions or concerns, please contact your community or state health or environmental quality department or:

For more information, contact:
Agency for Toxic Substances and Disease Registry
Office of Innovation and Analytics, Toxicology Section
4770 Buford Highway
Chamblee, GA 30341-3717
Phone: 1-800-CDC-INFO 888-232-6348 (TTY)
Email: Contact CDC-INFO

ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances.

Page last reviewed: August 30, 2023