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  Kumlinge   KUMV

Arbovirus

No

4

Placed in Level 4 based on the close antigenic relationship with a known Level 4 agent, Russian spring-summer encephalitis, plus insufficient laboratory experience.
Other Information
Vaccination Recommended 

B
Section VIII - Susceptibility to Experimental Infection (include viremia)
 
 
Experimental host and age Passage history and strain Inoculation Route-Dose Evidence of infection AST (days) Titer log10/ml


Mice (nb) MB 3 ic 0.01 Paralysis and death 4 9.8
Mice (nb) ip 0.03 Paralysis and death 5 9.0
Mice (nb) sc
Mice (wn) ic 0.03 Paralysis and death 5 9.1
Mice (wn) ip 0.1 Paralysis and death 6 8.0
guinea pig (2 mo) Antibody formation
chickens (7 days) sc Viremia up to 13 days(11) 6.6
chickens (ad.) sc Viremia in 2/12, 1/12 isolations from brain and gizzard after 2 years 4.3
Turdus merula (10 days) MB 2 sc 100LD50 Viremia in 1/4, antibody formation 2.7
Rana temporaria (ad) MB 3 sc 0.1 No virus detected
Bufo bufo (ad) sc 0.1 No virus detected
 
 
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