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Virus Name: Sindbis

Abbreviation: SINV

Status
Arbovirus

Select Agent
No

SALS Level
2

SALS Basis
Results of SALS surveys and information from the Catalogue.

Other Information

Antigenic Group
A

Section VIII - Susceptibility to Experimental Infection (include viremia)

Experimental host and age	Passage history and strain	Inoculation Route-Dose	Evidence of infection	AST (days)	Titer log10/ml


Cercopithecus aethiops and Macaca mulatta, young chickens and cattle egret (Bubulous ibis ibis) can be infected by bite of mosquito, circulate virus and develop NT antibodies. Crows (hooded) and doves susceptible to sc inoculation. One trial to infect sheep by mosquitoes failed. Adult hamsters and rabbits survive ic inoculation.
Chickens and pigeons circulate virus and death may result. Rabbits, rats, and marsupials are resistant (22). 42 of 53 S. African wild birds of 14 species circulated virus after im inoculation and developed antibodies (23).
* Strain isolated in South Africa was adapted to adult mice (8).

Mice (nb)	SMB 5	ic 0.02	Paralysis and death	2-4	7.5
Mice (nb)		ip 0.02	Paralysis and death	2-4	6.9
Mice (nb)		sc
Mice (wn)		ic 0.03	No deaths*
Mice (wn)		ip
emb. eggs(8 day)	SMB 3	ys 0.1	Death	1-3	6.0

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