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Gram Negative Carbapenemase Detection (CarbaNP)

This panel was assembled to challenge assays that detect carbapenemase production. Isolates in this collection represent a range of gram-negative bacteria; some producing a carbapenemase and others that demonstrate reduced susceptibility to carbapenems, but do not produce a carbapenemase. This collection was assembled to challenge assays that detect carbapenemase production.
Panel ID: CarbaNP

MICs obtained by broth microdilution. Modal MIC is reported.

MIC results for each antimicrobial agent for an isolate may commonly be ± 1 log2 (doubling dilution) different than what is posted on the FDA & CDC AR Bank website because this is the normal technical variability of antimicrobial susceptibility testing (see J. H. Jorgensen. 1993. J Clin Microbiol. Vol 31[11]: 2841-2844).

AR Bank #	Organism	Resistance Mechanisms	Biosample Accession #	Source
0032	Enterobacter cloacae	aac(3)-IIg, aac(6')-IIc, ACT-16, aph(3')-Ia, aph(6)-Id, ARR-2B, catA2, dfrA19, KPC-3, mcr-9.1, qacEdelta1, QnrB2, strA, sul1, sul2, TEM-1	SAMN04014873	Unknown
0033	Acinetobacter baumannii	ABAF, ant(3")-IIa, ble-MBL, NDM-1, OXA-94, sul2	SAMN04014874	Unknown
0034	Klebsiella pneumoniae	aac(3)-IId, aac(6')-Ib-G, catB3, EMRD, IMP-4, KDEA, mph(A), oqxA, oqxB25, qacEdelta1, qacG2, QnrB2, SHV-11, sul1, TEM-1	SAMN04014875	Urine
0035	Acinetobacter baumannii	ABAF, ADC-30, ADEC, aph(3')-Ia, aph(6)-Id, mph(E), msr(E), OXA-66, OXA-72, strA, sul2, TEM-1D, tet(B)	SAMN04014876	Unknown
0036	Acinetobacter baumannii	aac(6')-Ian, ABAF, ADC-214, ant(3")-IIa, aph(6)-Id, OXA-24, OXA-65, strA, sul2	SAMN04014877	Unknown
0037	Acinetobacter baumannii	ABAF, ADC-80, ant(2")-la, ant(3")-IIa, aph(3')-VI, ble-MBL, NDM-1, OXA-94, sul2	SAMN04014878	Unknown
0038	Enterobacter cloacae	aac(3)-IId, aac(6')-Ib, aadA1, aadA2, ACT-17, armA, ble-MBL, catB4, CTX-M-15, dfrA12, floR2, fosA, LAP-2, mph(E), msr(E), NDM-1, Omp36, OmpC, OmpC2, OmpK36, OXA-1, OXA-9, qacEdelta1, QnrS1, rmtB4, sul1, TEM-1, tet(G)	SAMN04014879	Urine
0039	Klebsiella pneumoniae	aac(3)-IId, aac(6')-Ib-cr, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, ARR-2, catA1, CTX-M-15, dfrA12, dfrA14, EMRD, ere(A), fosA5, KDEA, Omp35, OmpK35, oqxB9, oqxB9, OXA-181, qacEdelta1, SHV-26, sul1, sul2, tet(A), tet(R)	SAMN04014880	Urine
0040	Klebsiella pneumoniae	aac(3)-IIa, aac(6')-Ib-cr, aac(6')-Il, aph(3')-Ia, aph(6)-Id, catB4, CTX-M-15, dfrA1, EMRD, KDEA, mph(A), Omp35, OmpK35, oqxA, oqxB25, OXA-1, qacEdelta1, SHV-11, strA, sul1, tet(A), tet(R), VIM-27	SAMN04014881	Blood
0041	Klebsiella pneumoniae	aac(6')-IIa, aadA1, aph(3")-Ib, aph(3')-VI, aph(6)-Id, armA, ARR-2, ble-MBL, catB11, cmlA5, CMY-4, CTX-M-15, dfrA1, EMRD, fosA5, KDEA, mph(E), msr(E), NDM-1, oqxA, oqxB, OXA-10, qacEdelta1, SHV-11, sul1, sul2, tet(A), tet(R)	SAMN04014882	Nasal wash
0042	Klebsiella pneumoniae	aac(3)-IIa, aac(6')-Ib-cr, aadA1, aadA5, aph(3')-Ia, ARR-2, catA2, catB4, cmlA5, CTX-M-15, dfrA14, dfrA17, EMRD, erm(42), floR, fosA10, KDEA, mph(A), oqxA10, oqxB19, OXA-1, OXA-10, qacEdelta1, QnrS1, SHV-1, sul1, sul2, TEM-1	SAMN04014883	Unknown
0043	Klebsiella pneumoniae	EMRD, KDEA, oqxA, oqxB32, SHV-12	SAMN04014884	Unknown
0044	Klebsiella pneumoniae	aac(3)-IId, aac(6')-Ib, aadA1, catA1, catB4, CTX-M-15, dfrA14, EMRD, floR, fosA5, KDEA, Omp35, OmpK35, oqxA, oqxB25, OXA-1, OXA-9, SHV-11, sul2, TEM-1A	SAMN04014885	Unknown
0045	Acinetobacter baumannii	A1, A2, aac(3)-Ia, aadA1, ABAF, ADC-11, AMVA, ant(3")-IIa, aph(3')-Ia, catA1, OXA-23, OXA-69, qacEdelta1, sul1, TEM-1D, tet(A), tet(R)	SAMN04014886	Unknown
0046	Klebsiella pneumoniae	aac(3)-IIa, aac(6')-Ib-cr, aac(6')-Il, aph(3')-Ia, aph(6)-Id, catB4, CTX-M-15, dfrA1, EMRD, KDEA, mph(A), Omp35, OmpK35, oqxA, oqxB25, OXA-1, qacEdelta1, SHV-11, strA, sul1, tet(A), tet(R), VIM-27	SAMN04014887	Fluid drainage
0047	Klebsiella pneumoniae	aac(6')-Ib, aadA2, catA1, dfrA12, EMRD, KDEA, mph(A), Omp35, OmpK35, oqxA, oqxB, qacEdelta1, sul1, TEM-1A, tet(D)	SAMN04014888	Bronchial washings
0048	Escherichia coli	aac(6')-IB3, aadA2, ACRF, aph(3')-Ia, aph(6)-Id, ble-MBL, catA1, CMY-6, CTX-M-15, dfrA12, dfrA29, dfrA4, EMRD, NDM-1, OmpF, OXA-2, qacEdelta1, rmtC, strA, sul1, TEM-1, tet(B)	SAMN04014889	Unknown
0049	Klebsiella pneumoniae	aac(3)-IIa, aac(6')-Ib-D181Y, aadA2, aph(3')-Ib, aph(6)-Id, ble-MBL, catB4, CMY-6, CTX-M-15, dfrA14, EMRD, KDEA, mph(A), NDM-1, Omp35, OmpK35, oqxA, oqxB, OXA-1, qacEdelta1, QnrB9, rmtC, SHV-53, sul1, sul2, TEM-1, tet(A), tet(R)	SAMN04014890	Urine
0050	Enterobacter cloacae	aac(3)-Ib, ACT-24, aph(3')-Ia, dfrA14, dfrA15, KPC-4, LAP-2, qacEdelta1, qacF, QnrS1, sul1, TEM-1A	SAMN04014891	Unknown
0051	Klebsiella ozaenae	aac(3)-IId, aac(6')-Ib-cr, aadA1, aadA2, armA, ARR-2, catA1, CTX-M-15, dfrA12, dfrA14, EMRD, ere(A), fosA5, KDEA, Omp35, OmpK35, OXA-181, qacEdelta1, SHV-26, sul1, sul2, tet(A), tet(R)	SAMN04014892	Fluid drainage
0052	Acinetobacter baumannii	ABAF, ADC-79, ant(3")-IIa, OXA-100, OXA-58, sul2	SAMN04014893	Unknown
0053	Enterobacter cloacae	aac(6')-Ib, aadA1, ACT-45, aph(3")-Ib, aph(3')-Ia, aph(6)-Id, dfrA14, KPC-3, OmpF2, OXA-9, sul2, TEM-1A	SAMN04014894	Unknown
0054	Pseudomonas aeruginosa	ant(2")-la, aph(3')-IIb, aph(6)-Id, bcr1, bcr1, bcr1, catB7, fosA, mexA, mexE, mexX, OXA-396, PDC-3, sul1, sul1, sul1, tet(A), tet(R), tet(R), tet(R), VIM-4	SAMN04014895	Unknown
0055	Escherichia coli	aac(3)-IIa, aac(6')-Ib-D181Y, aadA5, ACRF, ble-MBL, catB4, CMY-6, dfrA17, mph(A), NDM-1, OXA-1, qacEdelta1, rmtC, sul1, tet(A), tet(R)	SAMN04014896	Urine
0056	Acinetobacter baumannii	aac(3)-IIe, ABAF, ADC-212, ADEC, aph(3')-Ia, aph(6)-Id, mph(E), msr(E), OXA-23, OXA-66, strA, sul2, tet(B)	SAMN04014897	Unknown
0057	Morganella morganii	aac(3)-IIa, aac(6')-Ib-cr5, aadA2, aadA5, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, ble-MBL, catA1, catB4, CTX-M-15, dfrA12, dfrA17, DHA-13, NDM-1, OXA-1, qacEdelta1, sul1, sul2, TEM-1, tet(B)	SAMN04014898	Wound
0058	Escherichia coli	aac(3)-IId, aadA5, ACRF, aph(3")-Ib, aph(6)-Id, dfrA17, mph(A), qacEdelta1, sul1, sul2, TEM-20, tet(A)	SAMN04014899	Unknown
0059	Proteus mirabilis	aadA1, aadA2, ant(2")-la, aph(3')-Ia, dfrA1, qacEdelta1, sat2, sul1, TEM-1, tet(J)	SAMN04014900	Sputum
0060	Enterobacter cloacae	ACT-89	SAMN04014901	Urine
0061	Escherichia coli	aac(6')-Ib, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, dfrA14, EMRD, KPC-3, OXA-9, qacEdelta1, sul1, sul2, sul3, TEM-1A, tet(A), tet(R)	SAMN04014902	Unknown
0062	Klebsiella aerogenes	aadA2, CMY2-MIR-ACT-EC, dfrA12, qacEdelta1, QnrB6, sul1, tet(A), tet(R)	SAMN04014903	Urine
0063	Acinetobacter baumannii	aac(6')-Ian, ABAF, ADC-114, ant(3")-IIa, OXA-23, OXA-24, OXA-65, sul2	SAMN04014904	Unknown
0064	Pseudomonas aeruginosa	aac(6')-Ib-AKT, aadA7, aph(3')-IIb, bcr1, catB7, cmx, fosA, mexA, mexE, mexX, OXA-50, OXA-56, PDC-5, qacEdelta1, SPM-1, sul1	SAMN04014905	Unknown
0065	Enterobacter cloacae	ACT-15	SAMN04014906	Urine
0066	Klebsiella pneumoniae	aac(3)-IId, aac(6')-Ib, aadA1, aph(3")-Ib, aph(6)-Id, ARR-2, catA1, catB4, cmlA5, CTX-M-15, dfrA1, EMRD, ere(A), fosA5, KDEA, Omp35, OmpK35, oqxA, oqxB20, OXA-1, OXA-232, OXA-9, qacEdelta1, sat2, SHV-11, sul1, sul2, TEM-1A	SAMN04014907	Wound
0067	Escherichia coli	ACRF, EMRD, OmpF, TEM-1B	SAMN04014908	Urine
0068	Klebsiella pneumoniae	aac(3)-IId, aac(6')-Ib, aadA1, aadA2, aph(3")-Ib, aph(3')-VI, aph(6)-Id, armA, ble-MBL, catA1, catB4, CTX-M-15, dfrA1, dfrA12, EMRD, fosA5, KDEA, mph(E), msr(E), NDM-1, oqxA, oqxB20, OXA-1, OXA-232, OXA-9, qacEdelta1, sat2, SHV-11, sul1, sul2, TEM-1A	SAMN04014909	Rectal swab
0069	Escherichia coli	aac(6')-IB3, ACRF, aph(3")-Ib, ble-MBL, CMY-6, dfrA8, EMRD, NDM-1, qacEdelta1, sul1, sul2, TEM-1, tet(A), tet(R)	SAMN04014910	Urine
0070	Acinetobacter baumannii	ABAF, ADC-79, ant(3")-IIa, MBL, OXA-100, OXA-58, sul2	SAMN04014911	Unknown
0071	Klebsiella oxytoca	Omp36, OmpC, OmpC2, OmpK36, OXY-2-8	SAMN04014912	Unknown
0072	Enterobacter cloacae	ACT-55	SAMN04014913	Urine
0073	Enterobacter cloacae	MIR-10	SAMN04014914	Sputum
0074	Klebsiella aerogenes	OXA-48	SAMN04014915	Fluid Peritoneal
0075	Klebsiella pneumoniae	aac(6')-Ib-G, ARR-6, catB, catB4, CTX-M-15, dfrA1, EMRD, KDEA, Omp35, OmpK35, oqxA, oqxB32, OXA-1, OXA-232, qacEdelta1, rmtF1, SHV-1, sul1, tet(A), tet(R)	SAMN04014916	Urine
0076	Klebsiella pneumoniae	aac(6')-Il, aadA1, aadA2, ant(2")-la, dfrA1, dfrA12, EMRD, fosA5, KDEA, mph(A), oqxA, oqxB19, qacEdelta1, QnrA1, SHV-30, sul1, VIM-1	SAMN04014917	Swab
0077	Escherichia coli	ACRF, EC-19, EMRD	SAMN04014918	Urine
0078	Acinetobacter baumannii	aac(3)-IIe, aac(6')-Ib, aadA11, ABAF, ADC-25, dfrB1, mph(E), msr(E), OXA-113, qacEdelta1, SHV-5, sul1	SAMN04014919	Pus
0079	Klebsiella pneumoniae	aac(3)-IId, aadA2, aph(3")-Ib, aph(6)-Id, CTX-M-14, dfrA12, DHA-1, EMRD, erm(42), floR2, KDEA, Omp35, Omp36, OmpC, OmpC2, OmpK35, OmpK36, oqxA, oqxB, qacEdelta1, rmtB1, SHV-11, sul2, TEM-1, tet(G)	SAMN04014920	Unknown
0080	Klebsiella pneumoniae	aac(3)-IId, aac(6')-Ib-G, aph(3")-Ib, aph(6)-Id, ARR-3, catB3, IMP-4, KDEA, OKP-B-21, OXA-1, qacEdelta1, qacG2, SFO-1, sul1, TEM-1	SAMN04014921	Urine
0081	Escherichia coli	ACRF, CMY-2, TEM-1	SAMN04014922	Urine
0082	Providencia rettgeri	aadA2, ble-MBL, dfrA12, NDM-1, qacEdelta1, sul1	SAMN04014923	Urine
0083	Acinetobacter baumannii	A1, A2, aac(3)-Ia, aadA1, ABAF, AMVA, ant(3")-IIa, aph(3')-Ia, aph(6)-Id, armA, ARR-2, ble-MBL, cmlA5, dfrA1, MBL, mph(E), msr(E), NDM-1, OXA-23, OXA-69, PER-7, qacEdelta1, sat2, strA, sul1, sul2, tet(B)	SAMN04014924	Unknown
0084	Escherichia coli	aadA5, ACRF, dfrA17, qacEdelta1, sul1, TEM-12	SAMN04014925	Urine
0085	Escherichia coli	aadA1, aph(3")-Ib, aph(6)-Id, CMY-2, dfrA1, EMRD, floR, MDTM, OmpF, sat2, sul2, tet(A), tet(B), tet(R)	SAMN04014926	Urine
0086	Escherichia coli	aac(3)-IId, aadA5, ACRF, aph(3")-Ib, aph(6)-Id, CTX-M-14, dfrA17, mph(A), qacEdelta1, sul1, sul2, TEM-1, tet(A)	SAMN04014927	Urine
0087	Klebsiella pneumoniae	EMRD, KDEA, Omp35, OmpK35, oqxA, oqxB20, QnrB1, SHV-12, tet(A), tet(R)	SAMN04014928	Urine
0088	Acinetobacter baumannii	aac(3)-IIe, aac(6')-Ian, ABAF, ADC-26, ant(3")-IIa, aph(3')-VI, aph(6)-Id, ble-MBL, NDM-1, OXA-64, strA, sul2, tet(B)	SAMN04014929	Unknown
0089	Escherichia coli	ACRF, aph(3")-Ib, aph(3')-Ia, aph(6)-Id, CMY-2, sul2, tet(B)	SAMN04014930	Urine
0090	Pseudomonas aeruginosa	aac(6')-33, ant(2")-la, aph(3')-IIb, bcr1, catB7, fosA, KPC-5, mexA, mexE, mexX, mph(E), msr(E), OXA-50, PDC-108, qacEdelta1, sul1	SAMN04014931	Wound
0091	Serratia marcescens	aac(6')-Ic, SMDA, SMDB, SME-4, SRT	SAMN04014932	Peritoneal dialysate
0092	Pseudomonas aeruginosa	aac(3)-Ic, aac(6')-IB3, aadA6, ant(2")-la, aph(3')-IIb, aph(3')-VI, bcr1, cmlA5, floR2, fosA, IMP-14, mexA, mexE, OXA-10, OXA-488, OXA-488, PDC-35, PDC-35, SMR, sul1, tet(G), VEB-9	SAMN04014933	Unknown
0093	Enterobacter cloacae	aac(3)-Ib, aac(6')-Ib-cr5, ACT-16, aph(3')-Ia, ARR-3, catB3, KPC-6, mph(A), OXA-1, qacEdelta1, qacF, sul1, TEM-1A	SAMN04014934	Urine
0094	Pseudomonas aeruginosa	aph(3')-IIb, bcr1, mexA, mexE, mexX, OXA-396, PDC-5	SAMN04014935	Wound
0095	Pseudomonas aeruginosa	aph(3')-IIb, bcr1, fosA, mexA, mexE, OXA-1022, PDC-12	SAMN04014936	Urine
0096	Klebsiella ozaenae	aac(6')-IB-AGKT, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, dfrA14, EMRD, fosA5, KDEA, KPC-3, oqxA, oqxB, OXA-9, qacEdelta1, SHV-1, sul1, sul2, TEM-1A	SAMN04014937	Urine
0097	Klebsiella pneumoniae	aac(6')-Ib, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, dfrA14, EMRD, fosA5, KDEA, KPC-3, oqxA, oqxB, OXA-9, qacEdelta1, SHV-11, sul1, sul2, TEM-1A	SAMN04014938	Urine
0098	Klebsiella pneumoniae	aac(3)-Iva, aac(6')-Ib, aadA1, aph(4)-Ia, catA1, cmlA1, dfrA12, EMRD, KDEA, KPC-2, mph(A), Omp35, OmpK35, oqxA, oqxB, OXA-9, qacEdelta1, qacL, SHV-12, sul1, sul3, TEM-1A	SAMN04014939	Urine
0099	Serratia marcescens	aac(6')-Ic, SMDA, SMDB, SME-4, SRT-2, SSME	SAMN04014940	Bronchial washings
0100	Pseudomonas aeruginosa	aac(3)-Id, aac(6')-Il, aadA6, aph(3')-IIb, bcr1, dfrB5, fosA, mexA, mexE, OXA-488, PDC-35, qacEdelta1, sul1, VIM-2	SAMN04014941	Unknown
0101	Acinetobacter baumannii	aac(6')-Ian, ABAF, ADC-214, ant(3")-IIa, aph(6)-Id, OXA-24, OXA-65, strA, sul2	SAMN04014942	Urine
0102	Acinetobacter baumannii	aac(6')-Ib-AKT, aadA1, ABAF, ADC-30, ADEC, aph(6)-Id, armA, catB8, mph(E), msr(E), OXA-66, qacEdelta1, strA, sul1, tet(B)	SAMN04014943	Urine
0103	Pseudomonas aeruginosa	aac(6')-Ib-G, ant(2")-la, aph(3")-Ib, aph(3')-IIb, aph(3')-VI, aph(6)-Id, bcr1, catB7, floR2, fosA, IMP-1, mexA, mexE, mexX, OXA-396, PDC-3, sul1, tet(A), tet(G), tet(R)	SAMN04014944	Unknown
0104	Escherichia coli	aadA5, ACRF, aph(3")-Ib, aph(3')-Ia, aph(6)-Id, dfrA14, dfrA17, KPC-4, mph(A), qacEdelta1, sul1, sul2, TEM-1A, tet(A)	SAMN04014945	Urine
0105	Pseudomonas aeruginosa	aadA1, aadA6, aph(3')-IIb, bcr1, fosA, mexA, mexE, OXA-2, OXA-488, PDC-35, qacEdelta1, sul1	SAMN04014946	Urine
0106	Klebsiella pneumoniae	aac(3)-IId, aac(6')-Ib, aadA1, aadA2, aph(3")-Ib, aph(3')-VI, aph(6)-Id, armA, ARR-2, ble-MBL, catB4, cmlA5, CTX-M-15, dfrA1, dfrA12, EMRD, ere(A), fosA5, KDEA, mph(E), msr(E), NDM-1, oqxA, oqxB20, OXA-1, OXA-9, qacEdelta1, sat2, SHV-28, sul1, sul2, TEM-1A	SAMN04014947	Rectal swab
0107	Klebsiella pneumoniae	aac(6')-IB-AGKT, aadA1, ARR-2, catA2, cmlA5, CTX-M-2, EMRD, fosA5, KDEA, Omp35, Omp36, OmpC, OmpC2, OmpK35, OmpK36, OXA-10, OXA-9, qacEdelta1, rmtG, SHV-187, sul1, sul2, TEM-1A	SAMN04014948	Unknown
0108	Pseudomonas aeruginosa	aac(3)-Id, aac(6')-Il, aadA2, aph(3')-IIb, bcr1, cmlA6, dfrB5, floR2, fosA, mexA, mexE, mexX, OXA-4, OXA-486, PDC-3, qacEdelta1, qacF, tet(G), VIM-2	SAMN04014949	Rectal swab
0109	Klebsiella pneumoniae	aac(3)-IIa, aac(6')-Ib-cr, aadA2, aph(3")-Ib, aph(6)-Id, catA2, catB4, CTX-M-15, dfrA12, dfrA14, EMRD, KDEA, mph(A), Omp36, OmpC, OmpC2, OmpK36, oqxA, oqxB, OXA-1, qacEdelta1, QnrB1, SHV-11, sul1, sul2, TEM-1, tet(D)	SAMN04014950	Unknown
0110	Pseudomonas aeruginosa	aac(3)-Id, aac(6')-Il, aph(3')-IIb, bcr1, dfrB5, floR2, fosA, mexA, mexE, mexX, OXA-486, PDC-3, qacF, sul1, tet(G), VIM-2	SAMN04014951	Rectal swab
0111	Pseudomonas aeruginosa	aac(3)-Id, aac(6')-Il, aadA2, aph(3')-IIb, bcr1, cmlA6, dfrB5, floR2, fosA, mexA, mexE, mexX, OXA-4, OXA-486, PDC-3, qacEdelta1, qacF, tet(G), VIM-2	SAMN04014952	Rectal swab

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CDC & FDA Antimicrobial Resistance Isolate Bank

Gram Negative Carbapenemase Detection (CarbaNP)

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