ID#: 14903
Caption:
At the component level, this diagram illustrates two different direct hemagglutination reactions, a positive viral hemagglutination assay (HA) reaction (above), and a negative viral HA reaction (below). The former involves a hemagglutinating virus, while the latter involves the implementation of a non-hemagglutinating virus, and how each interacts directly with red blood cells. Using the direct agglutination test, the agglutinating antibodies on the surface of the viral particles, or virions, react directly with antigens on the surface of the erythrocytes, or RBCs, forming visible clumps of particles. Indirect, or passive, hemagglutination tests involve agglutinating antibodies on the viral particle surface, reacting with antigens that have been passively coupled to carrier particles such as RBCs, forming visible clumps.
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Content Provider(s): CDC/ Dr. F.T. Forrester
Creation Date: 1975
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