ID#: 14990
Caption:
This illustration depicts what takes place during a neutralization reaction test with viruses, which is used to determine the presence of an antigen-antibody complex within a serum sample, and whether or not, when the serum sample is used as an inoculum, there is a subsequent cytopathic affect. At the top half of the diagram, the viral organisms combined with a specific antibody present in the serum sample, rendering the viruses unable to deliver their toxic effects to the rodent host. You can see that there is no ensuing cytopathic effect when the rodent is inoculated with this serum mixture. In the lower half of the diagram, you will note that the same test yields a cytopathic effect when another serum sample, containing no specific antibodies, is added to the virus. In this case, no virus-antibody complex is formed, and the virus remains free to deliver its cytopathic effect when the host is inoculated with this mixture.
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Content Provider(s): CDC/ Dr. Francis Forrester
Creation Date: 1974
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