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All Isolate Panels

    

Order pre-assembled resistance panels from CDC’s isolate collection below.

Isolates are gathered through CDC’s outbreak response and surveillance programs, validated and sequenced for testing, and then thoughtfully curated to increase lab efficiencies and public health innovations. The isolates represent samples from healthcare-associated, foodborne, gonorrhea, and community-associated infections.

Panel Action
Enterobacterales Carbapenemase Diversity (53)

The panel consists of carbapenemase-producing Enterobacterales. Isolates were selected to represent a diversity of species and carbapenemases. Panel ID: CRE

Aminoglycoside/tetracycline Resistance (40)

A panel of gram-positive and gram-negative bacteria with various molecular mechanisms of resistance to aminoglycoside and tetracycline drugs. This panel can be used to challenge novel aminoglycoside and tetracycline candidates to evaluate for cross-resistance across different drugs in the same class. Panel ID: ATR. NEW Additions: omadacycline and eravacycline MICs!

Isolates with New or Novel Antibiotic Resistance (17)
This is a collection of isolates with new or novel antibiotic resistance. The antibiotic resistance may be a new or novel resistance mechanism or phenotype. Panel ID: NEW
Meropenem/vaborbactam Verification (28)

A panel of Escherichia coli, Enterobacter cloacae and Klebsiella pneumoniae with different susceptibility to meropenem/vaborbactam. This panel can be used verification and for “in-house” validation of meropenem/vaborbactam antimicrobial susceptibility testing methods. Panel ID: MEV ***THIS PANEL IS CURRENTLY OUT OF STOCK. EXPECTED AVAILABILITY 12/1/22***

Acinetobacter baumannii (41)

This panel of Acinetobacter baumannii isolates were chosen to represent a diversity of antimicrobial susceptibility results for drugs that are used to treat infections. Panel ID: ACI

Clostridioides difficile EIP 2016 (30)

This panel contains 30 Clostridioides difficile isolates collected in the United States through the Emerging Infections Program at the Centers for Disease Control & Prevention. The selected isolates are a representative set of the top 10 most prevalent PCR-ribotypes collected in 2016. Panel ID: CDI Characterization of Clostridioides difficile Isolates Available through the CDC & FDA Antibiotic Resistance Isolate Bank | Microbiology Resource Announcements (asm.org): https://journals.asm.org/doi/full/10.1128/MRA.01011-20; https://journals.asm.org/doi/full/10.1128/mra.00302-22?af=R THIS PANEL IS OUT OF STOCK. EXPECTED AVAILABILITY:12/19/22

Gram Negative Carbapenemase Detection (80)

This panel was assembled to challenge assays that detect carbapenemase production. Isolates in this collection represent a range of gram-negative bacteria; some producing a carbapenemase and others that demonstrate reduced susceptibility to carbapenems, but do not produce a carbapenemase. This collection was assembled to challenge assays that detect carbapenemase production. Panel ID: CNP

Enterobacterales Carbapenem Breakpoint (31)

This panel was assembled to challenge tests that assess carbapenem susceptibility of Enterobacterales. Isolates in this collection demonstrate a range of carbapenem susceptibility. The carbapenem-resistant isolates also have different resistance mechanisms (i.e., some isolates produce a carbapenemase and others do not). Panel ID: BIT

Tedizolid/Linezolid (Oxazolidinones) Resistant Staphylococci (30)

This is a panel of Staphylococcus species resistant to linezolid and/or having variable susceptibility to tedizolid. This panel can be used for “in-house” validation of tedizolid and to challenge diagnostic tests that measure linezolid resistance in Staphylococci. Panel ID: TLZD ***THIS PANEL IS OUT OF STOCK. EXPECTED AVAILABILITY 9/30/22***

Salmonella enterica serovar Infantis (8)

This panel of Salmonella Infantis includes isolates with different of antimicrobial susceptibility to drugs that are used to treat infections and drugs that are tested for surveillance purposes. Isolated were collected from surveillance programs in the United States. Panel ID: SIN

Ceftolozane/tazobactam (30)

A panel of gram-negative bacteria with different susceptibility to ceftolozane/tazobactam. This panel can be used for “in-house” validation of ceftolozane/tazobactam antimicrobial susceptibility testing methods. Panel ID: CTV

Vancomycin-Resistant Enterococci (VRE) (30)

A panel of Enterococcus strains with VanA, VanB or VanC mediated resistance to vancomycin. Panel ID: VRE

Cefepime/ zidebactam (32)

A panel of gram-negative bacteria with varying susceptibilities to cefepime/zidebactam. This panel can be used for “in-house” validation of cefepime/zidebactam antimicrobial susceptibility testing methods. Isolates were selected to represent a diversity of species and resistance mechanisms including carbapenemases. Panel ID: FPZ Cefepime/zidebactam MICs reflect MIC of the combination.

Staphylococcus with Borderline Oxacillin Susceptibility (32)

This is a panel of Staphylococcus aureus isolates with variable susceptibility to oxacillin. Isolates with mecA-mediated oxacillin resistance are ones for which the MIC is close to the resistant breakpoint. This panel can be used as a rigorous challenge of diagnostic tests that measure oxacillin susceptibility or mecA-mediated resistance. Panel ID: BORSA

IMP-Type Metallo-ß-Lactamase (9)

Isolates harboring IMP-type metallo-ß-lactamases collected through the CDC’s Antibiotic Resistance Laboratory Network (AR Lab Network). This collection was assembled to challenge detection of difficult IMP variants not present in other AR Bank panels. Please note: Some of these variants may not reliably be detected by all commercial tests. Panel ID: IMP

Vancomycin Intermediate Staphylococcus aureus (14)

This collection of VISA isolates is meant to challenge diagnostic devices that test for S. aureus susceptibility to vancomycin. For all isolates in this panel the vancomycin MIC is 4 or 8 µg/mL. Please note, the VISA phenotype is typically unstable with repeat passage of an isolate. These isolates were chosen for their relatively stable phenotype, but care should be taken not to subculture the isolates excessively (e.g., greater than 3 times) before testing. Panel ID: VISA

Imipenem/relebactam (28)

A panel of gram-negative bacteria with different susceptibility to Imipenem/relebactam. This panel can be used for “in-house” validation of Imipenem/relebactam antimicrobial susceptibility testing methods. Panel ID: IMR

Pseudomonas aeruginosa (55)

This panel of Pseudomonas aeruginosa isolates were chosen to represent a diversity of antimicrobial susceptibility results for drugs that are used to treat infections. Panel ID: PSA

Enteric Pathogen Diversity (30)

This panel of pathogens includes isolates of Salmonella spp, Shigella spp., Campylobacter spp., and Escherichia coli O157. The isolates included demonstrate varied susceptibility patterns to antibiotics. These susceptibility patterns are representative of the diversity of susceptibility identified in surveillance isolates collected in the United States. Panel ID: GI ***PANEL IS CURRENTLY OUT OF STOCK***

Neisseria gonorrhoeae (50)

This panel of Neisseria gonorrhoeae isolates were chosen to represent a diversity of antimicrobial susceptibility results for drugs that are used to treat infections. Panel ID: GC

Multi-site Gram-negative Surveillance Initiative (MuGSI) - ESBL (29)

A panel of Escherichia coli, Klebsiella pneumoniae and Klebsiella oxytoca isolates with resistance to at least one extended-spectrum cephalosporin (ceftazidime, cefotaxime, or ceftriaxone) and non-resistant (i.e., susceptible or intermediate) to carbapenems. Some isolates harbor extended- spectrum beta-lactamases (ESBLs) and were collected in 2017, through the Multi-site Gram-negative Surveillance Initiative (MuGSI), part of the CDC’s Emerging Infections Program (EIP) Healthcare-Associated Infections Community Interface (HAIC) activity. Panel ID: ESBL

Ceftazidime/avibactam (30)

A panel of gram-negative bacteria with different susceptibility to ceftazidime/avibactam. This panel can be used for “in-house” validation of ceftazidime/avibactam antimicrobial susceptibility testing methods. Panel ID: CZA

Candida auris (30)

A panel of Candida auris isolates and other yeast species that are related to C. auris or are commonly misidentified as C. auris. Panel ID: CAU Caution: C. auris has been shown to be transmitted in healthcare settings. It is a good colonizer of skin and can live for up to four weeks on fomites. Gloves and gowns should be worn when working with C. auris, and working in a hood or a biological safety cabinet is recommended to avoid laboratory contamination. Since products with C. albicans or fungicidal claims may not be effective against C. auris, 10% bleach or products with EPA approval for C. auris should be used for cleaning the work area.

WHO Neisseria gonorrhoeae Reference (14)

The WHO gonococcal reference strains are intended for internal and external quality assurance and quality control in phenotypic (e.g. culture, species determination) and molecular diagnostics, molecular AMR detection, molecular epidemiology and as fully characterized, annotated and finished reference genomes in WGS analysis, transcriptomics, proteomics and other molecular technologies and data analysis. The minimum inhibitory concentration(MIC) of the WHO reference panel was established and published by the World Health Organization using Etest https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079299/ The MICs posted on this website are generated by agar dilution. For antimicrobial susceptibility testing comparison, please use the WHO published modal MICs. Panel ID: WHO

Shigella sonnei and Shigella flexneri (30)

A set of 30 Shigella isolates from the National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS), a US public health surveillance system that monitors antimicrobial resistance among enteric bacteria. Isolates in this collection represent different mechanisms of resistance to fluroquinolones and a range of susceptibility to fluroquinolones and azithromycin. Panel ID: SHG

Plazomicin (30)

A panel of gram-negative bacteria with different susceptibility to plazomicin. This panel can be used for “in-house” validation of plazomicin antimicrobial susceptibility testing methods. Panel ID: PLZ

Neisseria species MALDI-TOF Verification (30)

This panel contains a representative number of Neisseria species including 6 N. gonorrhoeae, 4 N. meningitidis, 17 other Neisseria species, 1 Kingella denitrificans, and 2 Moraxella catarrhalis. This will allow PHLs to have access to a rare collection of commensal Neisseria species for identification verification purposes. This panel can be supplemented with additional Neisseria gonorrhoeae strains : https://wwwn.cdc.gov/ARIsolateBank/Panel/PanelDetail?ID=1158 Panel ID: NID

Neisseria gonorrhoeae Ciprofloxacin (14)

The panel consists of 14 isolates with a selection of mutations in the resistance determinants for CIP, gyrA and parC. It is designed for diagnostic test developers to test gene specific tests for ciprofloxacin resistance/susceptibility based on these genes. Panel ID: NCIP

Difficult-to-Detect Staphylococcus aureus harboring mecA (30)

A panel of mecA-harboring Staphylococcus aureus isolates with varying susceptibility results to cefoxitin. https://jcm.asm.org/content/58/4/e02038-19 Panel ID: DTD

Delafloxacin (60)

A panel of Gram-positive and Gram-negative bacteria with different susceptibility to delafloxacin. This panel can be used for “in-house” validation of delafloxacin antimicrobial susceptibility testing methods. Panel ID: DLX

Drug Resistant Candida species (45)

This is a panel of primarily C. glabrata and C. parapsilosis isolates demonstrating resistance to azoles or echinocandins. Susceptible isolates of the same species are included. Panel ID: CAN

Aspergillus fumigatus (10)

A panel of Aspergillus fumigatus isolates with TR34 /L98H mutation in the CYP51A gene which confers resistance to azole antifungals. Panel ID: ASP


Please note:
MIC results for each antimicrobial agent for an isolate may commonly be ± 1 log2 (doubling dilution) different than what is posted on the FDA-CDC AR Bank website because this is the normal technical variability of antimicrobial susceptibility testing (see J. H. Jorgensen. 1993. J Clin Microbiol. Vol 31[11]: 2841-2844). MICs obtained by a user could possibly show an even greater difference than this, depending on the methodology, the modal MIC of the isolate, and if the MIC on the website is at a very low or very high testing range. However, major (resistant versus susceptible) or very major (susceptible versus resistant) interpretive category difference for a given drug-organism result should be uncommon (i.e., this could occur in the rare occasions where the susceptible and resistant breakpoints are within a single doubling dilution). In other cases a major or very major error likely indicates a problem with either the organism (e.g., losing a resistance mechanism upon passage) or the testing method being applied. The MIC results provided for each isolate were generated using frozen broth microdilution panels unless otherwise specified.


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