ID#: 23668
Caption:
This photograph depicts a close anterior view of the left lower leg of a 4-month-old female infant born with a rare X-linked dominant genetic disorder known as incontinentia pigmenti (IP). The disorder results from a mutation in the IKBKG (inhibitor of nuclear factor kappa B kinase subunit gamma) gene, which regulates production of IκB kinase (IkappaB kinase or IKK), a critical component of the cellular inflammatory response pathway. The infant exhibited characteristic dry, scaly, erythematous lesions involving the lower extremity. See PHIL 23664 through 23671 for additional views documenting this infant’s condition at various stages of development.
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Content Provider(s): CDC/ Mr. Gust
Creation Date: 1967
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Copyright Restrictions: None - This image is in the public domain and thus free of any copyright restrictions.