Data documentation and Data files
DNA methylation (DNAm) was measured from DNA purified blood collected from NHANES participants during the 1999–2000 and 2001–2002 cycles. DNAm was measured using the Illumina EPIC BeadChip array. Methylation data matrices were produced, pre-processed, and normalized. DNAm derived epigenetic biomarkers predicting chronological age, phenotypic age, telomere length, pace of aging, mortality, and mitotic cell turnover rate were produced.
For information about the NHANES DNAm array and resulting data files, review the DNA Methylation Array and Epigenetic Biomarkers Data Documentation. The documentation describes eligible samples, laboratory procedures, bioinformatics procedures, and analytic notes; plus, it provides a dictionary of terms and a process flow chart.
The public use data file is available below. The restricted data file is indicated as such in the table below. Proposals to analyze the restricted DNAm data file may be submitted to the NCHS Research Data Center (RDC). For additional information on restricted-use data proposal submission guidelines, please go to the RDC website.
Questions: Email NHANESGenetics@cdc.gov